Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase

Membrane - type Matrix Metalloproteinase - 3 Regulates

the investigation of the relationship between type a and type b personalities and quality of translation

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Matrix Metalloproteinase Collagenase/Gelatinase A by a Recombinant Membrane-Type 1 Processing of a Precursor of 72-Kilodalton Type IV

Membrane-type 1 matrIx metalloproteinasethat is associatedwith the proteolytic activation of progelatlnase A was expressed as a recombinant fusion protein in Escherichia coiL The recombinant enzyme cleaved the propeptide sequence of gelatinase A in a sequence-specific manner. A mutant progelatinase A that has a substitution ofAsnss@Leu to ile-Val was not processed at all. The processing was blo...

Heterologous expression of a truncated form of human recombinant vascular endothelial growth factor-A and its biological activity in wound healing

Objective(s): Vascular endothelial growth factor (VEGF) is one of the most effective proteins in angiogenesis, mesenchymal stem cells (MSCs) differentiation and wound healing. These abilities are therapeutic potential of VEGF in diabetic retinopathy, nephropathy and other tissue damage circumstances. In this study, recombinant VEGF was produced in Escherichia coli (E. coli) system and then biol...

Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.

Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-binding integrins in this event, we treated DOV 13 cells with soluble beta1 integri...